Ideas that move the mission forward

Explore our thoughts on investment, innovation, and mission.

Writing
Podcasts
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Announcing Spero Ventures Fund II
Writing

Announcing Spero Ventures Fund II

by Shripriya Mahesh and Andrew Parker •

Continuing our efforts to support companies building a healthy, sustainable, and fulfilling future.

Opportunities in Tech-Bio
Writing

Opportunities in Tech-Bio

by Nolan Shah •

The technologies making it faster, better, and cheaper to get life-saving medicines to patients.

In A Post-AI World, Who Are You Building For?
Writing

In A Post-AI World, Who Are You Building For?

by Shripriya Mahesh •

Discover how the rise of AI agents will transform your everyday shopping, from toilet paper to toothpaste, and uncover the key transactions that will resist automation.

Exposomics
Writing

Exposomics

by Nolan Shah •

Science's next moonshot.

Scaling Specialty Care
Writing

Scaling Specialty Care

by Nolan Shah •

Hinge Health's IPO and how we think about tech-enabled services.

Beginner’s Mind
Writing

Beginner’s Mind

by Shripriya Mahesh •

Discover the challenges and rewards of starting over, from developing new skills to bridging the gap between taste and capability, as one navigates a major career transition.

Marc on Telo Talks
Podcasts

Marc on Telo Talks

Discover the latest insights from investors, partners, and industry experts on the fast-growing Telo Talks Podcast - now with offline listening.

It Never Gets Easier
Writing

It Never Gets Easier

by Shripriya Mahesh •

Discover the surprising truth behind the startup founder's pursuit of the 'next level' – how achieving major milestones often fails to deliver the transformative impact imagined, as we quickly adjust to the new normal.

Ethical and Empathetic Investing with Shripriya Mahesh
Podcasts

Ethical and Empathetic Investing with Shripriya Mahesh

Shripriya and Matt Munson explore the mental elements of going after big missions through the lens of her work at Spero and her early-career role as the head of product for eBay. We also explore ideas about self-care in relation to work, care for founders as an investor, and the importance of finding a clear mission.

Shripriya on All in a day’s work (2024)
Podcasts

Shripriya on All in a day’s work (2024)

NYU student Pushpavalli Annamalai speaks with Shripriya Mahesh, who is the General Partner of Spero Ventures. Shripriya shares her fascinating and diverse journey from photography to entrepreneurship. She also shares her insights from what makes a good product design.